Additional file 6 of Long-term LVEF trajectories in patients with type 2 diabetes and heart failure: diabetic cardiomyopathy may underlie functional decline JuliánMaría Teresa AlonsoNúria LupónJosep Gavidia-BovadillaGiovana FerrerElena de AntonioMarta López-AyerbeJorge DomingoMar Santiago-VacasEvelyn ZamoraElisabet CodinaPau MolinerPedro NúñezJulio SantesmasesJavier Puig-DomingoManel Bayes-GenisAntoni 2020 Additional file 6: Figure S3. Loess spline curves of long-term LVEF trajectories based on sex. Panel B: Women. P value for trajectory changes on LVEF <0.001 for both groups. P for comparison between groups (interaction between trajectory changes and diabetes) = 0.14. Shaded regions displayed around curves represent the confidence interval at level = 0.95.