Additional file 1 of A metabolic switch regulates the transition between growth and diapause in C. elegans Sider Penkov Bharath Kumar Raghuraman Cihan Erkut Jana Oertel Roberta Galli Eduardo Jacobo Miranda Ackerman Daniela Vorkel Jean-Marc Verbavatz Edmund Koch Karim Fahmy Andrej Shevchenko Teymuras V. Kurzchalia 10.6084/m9.figshare.12004692.v1 https://springernature.figshare.com/articles/journal_contribution/Additional_file_1_of_A_metabolic_switch_regulates_the_transition_between_growth_and_diapause_in_C_elegans/12004692 Additional file 1: Figure S1. Heat flow of C. elegans undergoing reproductive growth or developmental arrest. Left panels - biological replicates generated in various experiments. Right panels - corresponding median heat flow per experiment. Curves representing median values have been smoothed using generalized additive models. a Heat flow produced by wild-type (N2) worms undergoing reproductive growth on cholesterol or dauer formation on 4-MS (4-methylated sterol). Corresponding to Fig. 1b. b Heat flow of daf-2 and daf-7 grown at 25 °C in the presence or absence of DA. c Heat flow of daf-2, daf-2;daf-12 and daf-2;daf-16 grown at 25 °C. Corresponding to Fig. 1d. 2020-03-19 04:48:59 AAK -2 ratio enzyme elegans Abstract Background Metabolic activity TCA cycle quiescence hormone receptor DAF -12 controls dauer morphogenesis shift transition pathway gluconeogenesi