10.6084/m9.figshare.11497521.v1
Brianna Craver
Brianna
Craver
Thanh Nguyen
Thanh
Nguyen
Jenny Nguyen
Jenny
Nguyen
Hellen Nguyen
Hellen
Nguyen
Christy Huynh
Christy
Huynh
Sarah Morse
Sarah
Morse
Angela Fleischman
Angela
Fleischman
MOESM2 of The SMAC mimetic LCL-161 selectively targets JAK2V617F mutant cells
Springer Nature
2020
Myeloproliferative neoplasm
SMAC mimetic
TNFα
2020-01-03 04:55:32
Journal contribution
https://springernature.figshare.com/articles/journal_contribution/MOESM2_of_The_SMAC_mimetic_LCL-161_selectively_targets_JAK2V617F_mutant_cells/11497521
Additional file 2: Figure S2. Expression levels of cIAP1/2 or XIAP do not influence sensitivity of human cell lines to LCL-161. Western blot of K562 (BCR-ABL mutant) and HEL (JAK2V617F) cells treated with 10 nM LCL-161 for 2 h before protein isolation. LCL-161 reduces expression of cIAP1 and cIAP2 in both cell lines as expected. XIAP expression was unaffected by LCL-161.